COVID-19 Scan for Jun 27, 2022

Folks with Down syndrome at greater danger for extreme COVID-19

The Journal of Infectious Ailments has revealed research demonstrating decrease COVID-19 incidence—however the next danger of extreme illness—in individuals with Down syndrome (DS), and a decrease COVID vaccine immune response.

Within the first matched cohort research, primarily based on knowledge collected from the Kaiser Permanente system in California, 2,541 individuals with DS and 10,164 with out DS had been matched by age, intercourse, and race/ethnicity. The research was carried out from Mar 1, 2020, to Dec 31, 2020, earlier than COVID-19 vaccines had been obtainable and earlier than SARS-CoV-2 variants had been broadly circulating.

Folks with DS had been 32% much less more likely to contract COVID-19 than non-DS matches (adjusted hazard ratio [aHR], 0.68; 95% confidence interval [CI], 0.56 to 0.83,) however that they had extreme COVID-19 six instances extra typically (aHR, 6.14; 95% CI; 1.87 to twenty.16).

The authors stated caregivers of these with DS doubtless practiced stricter COVID-19 precautions than others, accounting for the decrease total an infection charges, however anatomical adjustments seen in individuals with DS—together with to the cardiovascular system—might clarify why the illness is extra extreme in that group.
Jun 24 J Infect Dis severity

Within the second research, vaccine antibody ranges in Dutch DS sufferers had been in comparison with matched non-DS friends. Blood samples had been collected at baseline, inside 28 days of first vaccination dose, and 28 days after the second vaccine dose for 318 contributors, 214 of whom had DS.

The authors stated the DS inhabitants produced fewer antibodies than the non-DS group, and antibody ranges had been negatively correlated with age within the DS group, with these over 40 displaying decrease antibody ranges than youthful adults with DS. The identical drop was not seen in non-DS adults over the age of 40.

“Antibody responses after SARS-CoV-2 vaccination in adults with DS are considerably decreased in contrast with wholesome adults. In older adults with DS the decreased antibody responses had been much more pronounced, which, mixed with the very best mortality charges, makes this group notably susceptible,” the authors concluded.

“A 3rd or early booster vaccination needs to be thought-about in all adults with DS, given their danger for extreme illness after SARS-CoV-2 an infection.”
Jun 24 J Infect Dis vaccine study

Pfizer releases promising findings on Omicron boosters

Forward of a Meals and Drug Administration (FDA) vaccine advisory committee assembly tomorrow to debate up to date COVID-19 vaccines, Pfizer and BioNTech launched promising findings on two of their booster candidates focusing on the Omicron SARS-CoV-2 variant.

The vaccine candidates that embody an Omicron-adapted monovalent (single-strain) vaccine given as a fourth booster dose at 30-microgram and 60-microgram doses elevated neutralizing geometric titers in opposition to BA.1 13.5-fold and 19.6-fold, respectively. The bivalent (two-strain) vaccine confirmed a rise of 9.1-fold and 10.9-fold improve, respectively. Early lab research confirmed each vaccines neutralized BA.4 and BA.5 subvariants, however lesser than for BA.1.

The proportions of BA.4 and BA.5 are rising in the USA, with the 7-day common for brand spanking new each day instances is up 9% from every week in the past. In the meantime, the Facilities for Illness Management and Prevention (CDC) stated on Jun 24 that 58% of the US inhabitants lives in an space with medium or excessive group transmission, down a bit from 61% the week earlier than.

In worldwide developments, the UK Well being Safety Company (HAS) stated on Jun 24 that BA.4 and BA.5 subvariants are actually dominant in Britain, with BA.5 rising the quickest and anticipated to grow to be dominant. The HSA urged individuals to ensure their vaccine standing is updated. Elsewhere, Pakistan is now requiring masks for home air journey, given a gentle rise in COVID-19 instances.
Jun 25 Pfizer-BioNTech press release
FDA Vaccines and Associated Organic Merchandise Advisory Committee
meeting materials
Washington Publish COVID-19
Jun 24 CDC
Jun 24 UK HSA
Jun 27 Reuters



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