COVID-19 Scan for Mar 21, 2022

Alcohol deaths elevated throughout first 12 months of COVID-19 pandemic

Alcohol-related deaths elevated by 25% in the US throughout the first 12 months of the COVID-19 pandemic, based on a brand new research in JAMA based mostly on information from the Nationwide Heart for Well being Statistics.

A number of research have proven that alcohol use elevated throughout the first month of COVID-19 lockdowns, however this research confirmed that deaths associated to overconsumption of alcohol jumped from 2019 to 2020, from 78,927 to 99,017 [relative change, 25.5%]), as did the age-adjusted fee (from 27.3 to 34.4 per 100,000 [relative change, 25.9%]).

Alcohol-related deaths accounted for two.8% of all deaths in 2019 and three.0% in 2020. The findings echo earlier research on opioid use throughout the pandemic, which discovered that opioid overdose deaths elevated 38% in 2020.

Although charges of alcohol-related deaths elevated equally amongst women and men, there have been vital will increase for individuals aged 35 to 44 years (from 22.9 to 32.0 per 100,000 [39.7%]) and 25 to 34 years (from 11.8 to 16.1 per 100 000 [37.0%]).

“The speed enhance for alcohol-related deaths in 2020 outpaced the rise in all-cause mortality, which was 16.6%,” the authors wrote. “Deaths involving alcohol mirror hidden tolls of the pandemic. Elevated ingesting to deal with pandemic-related stressors, shifting alcohol insurance policies, and disrupted therapy entry are all potential contributing elements.”
Mar 18 JAMA study

Accuracy of second SARS-CoV-2 fast antigen take a look at estimated at 94%

The estimated general accuracy of a second COVID-19 fast antigen take a look at amongst asymptomatic New York Metropolis staff was 94% in a comparative effectiveness research printed late final week in JAMA Community Open.

The research authors famous that whereas the gold-standard diagnostic take a look at for COVID-19 is real-time quantitative polymerase chain response (RT-qPCR), fast antigen exams are sometimes used to display asymptomatic populations as a result of they produce outcomes quicker and are inexpensive.

“Though fast antigen exams have been criticized for poor sensitivity and specificity when screening asymptomatic sufferers, a information hole nonetheless stays relating to the utility of those exams for screening,” they wrote.

Led by a Weill Cornell Drugs researcher, the workforce examined 179,127 contributors in a office screening program utilizing Sofia2 SARS Antigen Fluorescent Immunoassay, LumiraDX, and BinaxNow exams at a global service firm from November 2020 by October 2021. Median worker age was 36 years, and 58% had been males.

Of the 179,127 antigen exams carried out, 623 (0.35%) yielded optimistic outcomes, of which 238 (38%) had been confirmed to be optimistic by RT-qPCR, and 385 (62%) had been discovered to be false-positive.

Among the many 623 optimistic antigen take a look at outcomes, 569 (91%) had been adopted by a second such take a look at. Of 224 pairs of consecutive antigen exams with optimistic outcomes, RT-qPCR outcomes had been optimistic for 207 (92%). Within the 345 instances with a primary optimistic antigen take a look at adopted by a detrimental take a look at, 328 (95%) had been detrimental on RT-qPCR. Whole estimated accuracy of a repeat antigen take a look at was 94%.

“The outcomes of this research demonstrated that when a repeated fast antigen take a look at was provided to contributors of an worker screening program, the estimated accuracy elevated from 38% to 92% for true-positive outcomes as decided by RT-qPCR for SARS-CoV-2,” the authors wrote.

A second antigen take a look at could also be helpful for guiding COVID-19 interventions, the researchers stated. “These findings could have necessary implications for a way fast antigen exams may be deployed for extra correct outcomes, particularly in a setting the place the time to outcomes is necessary and the place widespread PCR testing could also be value prohibitive,” they concluded.
Mar 18 JAMA Netw Open research letter

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