COVID-19 Scan for Could 11, 2022

Combine-and-match mRNA COVID vaccines could provide extra Omicron safety

Researchers in Singapore found {that a} Moderna COVID booster following a two-dose Pfizer vaccine sequence induced a stronger neutralizing antibody response in opposition to the Omicron variant in adults in contrast with an all-Pfizer sequence, in keeping with a examine at present in Scientific Infectious Illnesses.

The randomized managed trial included 100 wholesome adults who had accomplished their preliminary vaccination sequence with Pfizer-BioNTech’s mRNA vaccine, 6 to 9 months previous to this examine. Contributors had been assigned to get both a Pfizer booster or a Moderna booster in a few 1:1 ratio. The first finish level of the examine was the extent of neutralizing antibodies in opposition to SARS-CoV-2 wild-type and variants of concern at day 28 post-booster.

Imply SARS-CoV-2 spike antibody titers had been decrease within the Pfizer-only group—22,382 worldwide models per milliliter (IU/mL; 95% confidence interval [CI], 18,210 to 27,517), in contrast with 29,751 IU/mL within the Moderna group (95% CI, 25,281 to 35,011; P = 0.034).

Extra considerably, the group with a Moderna booster had greater antibodies in opposition to variants of concern, together with Omicron. The median surrogate neutralizing antibody degree in opposition to Omicron within the all-Pfizer group was 72.8%, in contrast with 84.3% within the mixed-vaccine group.

Contributors ages 60 and older confirmed a extra strong immune response to mixing than youthful individuals, the authors stated; in that group, three Pfizer doses supplied 64.6% safety in opposition to Omicron, in comparison with 89.2% for older adults who acquired a Moderna third dose.

“For the susceptible older age group particularly, a heterologous booster COVID-19 vaccine routine induces a better anti-spike antibody titer and a stronger neutralizing antibody response in opposition to the extremely infectious Omicron variant (~20% greater neutralization) than a homologous booster routine,” the authors concluded.
Could 11 Clin Infect Dis
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Youngsters’ odds of spreading COVID-19 in households rising with new variants

A scientific evaluate and meta-analysis printed at present within the Worldwide Journal of Infectious Illnesses means that whereas youngsters account for much less family COVID-19 transmission, their infectiousness seems to be on the rise as new SARS-CoV-2 variants emerge.

Researchers from the Nationwide Scientific Analysis Middle for Baby Well being and Problems in China led the examine, which concerned looking the PubMed and EMBASE databases from inception to Apr 20, 2022. Forty-eight research had been included for meta-analysis, and 47 had been chosen for case evaluation.

The pooled secondary assault price (SAR) of pediatric index sufferers and family members was 0.20 (95% confidence interval [CI], 0.15 to 0.26) and 0.24 (95% CI, 0.18 to 0.30), respectively, within the meta-analysis. SAR refers back to the chance of transmission to a different individual.

Baby index instances had a 36% decrease COVID-19 transmissibility threat than adults, and baby contacts had a 26% decrease threat (relative threat [RR], 0.64; 95% CI, 0.50 to 0.81 and RR, 0.74; 95% CI, 0.64 to 0.85, respectively). Youthful and older youngsters had been equally susceptible to an infection (RR, 0.89; 95% CI, 0.72 to 1.10).

Elevated family SAR was seen in youngsters all through totally different variant durations (wild-type virus, 0.20; Alpha, 0.42; Delta, 0.35; and Omicron, 0.56). The estimated SAR of grownup family contacts was 0.32 (95% CI, 0.27 to 0.37) in 41 research.

Older adults had been considerably tied to a better SAR than youthful adults (RR, 1.45; 95% CI, 1.24 to 1.70 for adults youthful than 60; RR, 1.24; 95% CI, 1.02 to 1.50 for older adults).

Within the case evaluation, 10.3% of 78 household clusters had been related to an contaminated baby, resulting in 7.7% of 207 secondary instances, versus 92.3% of these linked with an contaminated grownup. Pediatric infections had been implicated in 29.8% of 282 family contacts and 60.3% of 78 household clusters. Secondary infections unfold by youngsters made up 30% of 207 secondary infections, in contrast with 70% for adults.

“Given the doubtless severe problems of pediatric COVID-19, vaccination analysis and implementation in youngsters stay a should,” the researchers concluded.
Could 10 Int J Infect Dis study

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