Research: Paxlovid efficient for COVID-19, not tied to increased threat of rebound
The oral antiviral drug Paxlovid is secure and efficient for treating COVID-19 and carries no extra threat of viral rebound past different therapies, in line with a meta-analysis revealed late final week within the Journal of An infection.
Paxlovid is really useful for treating sufferers who’ve gentle or reasonable COVID-19 and are at excessive threat for extreme sickness. Circumstances of viral rebound after Paxlovid therapy have been broadly reported, together with that of US President Joe Biden, who examined optimistic for COVID-19 after Paxlovid therapy in July.
Researchers from Guizhou Medical College in Guiyang, China, led the meta-analysis of 13 managed trials that included 186,306 sufferers revealed from Dec 1, 2021, to Sep 20, 2022. The research in contrast the usage of Paxlovid with both ordinary care or a placebo and/or one other drug (eg, a distinct antiviral, monoclonal antibodies).
Of the 13 research, 3 discovered no distinction within the threat of viral rebound within the Paxlovid and management teams (odds ratio [OR] of rebound amongst Paxlovid sufferers vs controls, 0.99). 5 research on adverse-event charges recognized no distinction between the Paxlovid and management teams (OR, 1.07).
Among the many seven research on the effectiveness of Paxlovid in stopping loss of life or hospitalization, the OR of loss of life within the Paxlovid versus the management group was 0.12, indicating an 88% discount. The OR of hospitalization within the two teams was 0.32, a 68% discount after Paxlovid.
The examine authors stated that COVID-19 rebound isn’t distinctive to Paxlovid. “There was extra consideration to COVID-19 rebounds following Paxlovid therapy, which can be attributable to extra folks being handled with Paxlovid,” they wrote. “Nonetheless, the phenomenon of rebounds following Paxlovid therapy reinforces the significance of testing for people with recurrent signs after Paxlovid therapy.”
Sep 30 J Infect research letter
Healthcare employees skilled 3 instances as a lot burnout throughout pandemic
New analysis from the Queen Mary College of London and different UK researchers exhibits that even when charges of psychological well being points are related, healthcare professionals who labored throughout the COVID-19 pandemic have been 3.3 instances extra prone to expertise burnout than different professionals. The analysis is revealed in BJPsych Open.
The examine was primarily based on on-line surveys of UK professionals, which assessed anxiousness, despair, insomnia, burnout, and low emotional wellbeing. A complete of 1,574 healthcare employees and 147 non-healthcare professionals accomplished the survey. Seventy % of contributors have been feminine, and 70% have been over the age of 35. Two-thirds recognized as White (66%) and just below 1 / 4 recognized as Asian (22.3%).
The surveys have been performed in July by way of September of 2020, in November and December of 2020, and in early spring 2021, throughout a second UK nationwide lockdown.
There have been no vital variations in charges of tension or despair throughout every section, however healthcare employees had a 2.5-fold elevated threat of burnout throughout the second section of surveys (emotional exhaustion: odds ratio [OR], 2.50; 95% confidence interval [CI], 1.15 to five.46; P = 0.02), which elevated to a 3.3-fold elevated threat throughout the second UK lockdown (OR, 3.32; 95% CI, 1.40 to 7.87; P = 0.006).
Burnout decreased over time throughout the three intervals, however healthcare employees straight treating sufferers nonetheless had a 2.7-fold elevated threat of burnout by the second UK lockdown—the best stage amongst subgroups.
“Until we are able to cease the burnout development, we may see extra psychological well being and bodily penalties equivalent to cardiovascular and metabolic ailments in our docs, nurses, and different healthcare employees,” stated Ajay Gupta, MD, senior writer of the examine, in a Queen Mary College press launch.
Sep 30 BJPsych Open study
Sep 30 Queen Mary press release