Omicron subvariants linked to reinfections
A brand new examine based mostly on COVID-19 sufferers in France exhibits excessive reinfection charges amongst folks with completely different Omicron subvariants, together with BA.1, BA.2, and BA.5. The examine is printed as a analysis letter in Rising Infectious Ailments.
The analysis group conducting this examine, from Aix Marseille College, beforehand discovered reinfection charges had been 6-fold larger through the Omicron surge than in earlier variant surges. On this examine, the authors used a computerized alert system that recognized constructive case samples with major Omicron BA.1 or BA.2 subvariant infections adopted by reinfection with any Omicron subvariant.
They discovered 188 (0.7%) instances of reinfection out of 27,972 affected person samples that examined constructive for Omicron from Nov 28, 2021, to Jul 22, 2022. Of the 188 instances, 181 had been first contaminated with the Omicron BA.1 subvariant. Of these, 82 sufferers had been reinfected with Omicron BA.2, 14 had been contaminated with Omicron BA.4, 84 with Omicron BA.5, and 1 with a BA.1 and BA.2 recombinant subvariant (XAC recombinant lineage).
The median age of sufferers was 32, and 70% had been ladies. Time between two infections was lower than 90 days for 50 sufferers (26.6%) and fewer than 60 days for 28 sufferers (14.9%).
“Our findings point out that the time between confirmed major infections and reinfections with completely different Omicron subvariants is often shorter than the 90-day definition of reinfections utilized by the US Facilities for Illness Management and Prevention [CDC],” the authors concluded. “Moreover, the time may be shorter than the 60-day definition of reinfections utilized by the European Centre for Illness Prevention and Management.”
Sep 23 Emerg Infect Dis study
Pfizer/BioNTech asks FDA to authorize bivalent COVID booster for teenagers
Pfizer and BioNTech have requested the US Meals and Drug Administration (FDA) to authorize a bivalent COVID-19 booster for teenagers ages 5 to 11. The booster, already authorized for adults, is supposed to raised defend in opposition to Omicron variants of the virus.
Moderna has additionally submitted a request for approval to the FDA of their Omicron booster for teenagers ages 12 to 17 and youngsters 6 to 11. Solely 4.4 million grownup doses of the bivalent vaccines have been administered in america.
The 7-day common of latest each day COVID-19 instances is 50,749, with 398 each day deaths, in keeping with the Washington Publish tracker. Up to now week, new each day instances fell 11%, hospitalizations fell 5%, and deaths fell 3%.
Late final week, the CDC printed new steering that claims hospitals and nursing houses in counties with low COVID-19 transmission do not should require sufferers or workers to put on masks, CBS Information reported.
Sep 26 FDA booster Reuters story
Sep 23 CDC guidance
Sep 23 CBS story
Vaccines protected pregnant ladies in opposition to extreme COVID for 3 months
Pregnant ladies who acquired two or three doses of an mRNA COVID-19 vaccine had been properly protected in opposition to Delta- and Omicron-related hospitalization and emergency division (ED) and pressing care (UC) visits for greater than 3 months, however safety appeared to wane to zero by 4 months, exhibits a US test-negative case-control examine printed at the moment in JAMA Community Open.
The CDC COVID-19 Emergency Response Staff led the examine of 975 hospitalizations and 4,517 ED/UC visits by pregnant ladies for any trigger from June 2021 to June 2022, a interval that spanned the predominance of the extremely transmissible Delta and Omicron variants. Of the 975 hospitalizations, 34.3% had been for confirmed COVID-19, in contrast with 19.6% of the 4,517 ED/UC visits.
The ladies had been seen in a community of 306 hospitals and 164 ED/UC amenities in 10 states. They’d acquired a second dose of the Pfizer/BioNTech or Moderna COVID-19 vaccine at the very least 14 days earlier or a 3rd dose at the very least 7 days earlier or had been unvaccinated.
Throughout Delta, estimated VE in opposition to COVID-19 hospitalization was 99% for 2 doses after 14 to 149 days, 96% for 2 doses given at the very least 150 days earlier than, and 97% for 3 doses after 7 to 119 days. Estimated VE in opposition to ED/UC visits was 84%, 75%, and 81%, respectively.
Amid Omicron, estimated VE in opposition to hospitalization was 86% for 2 doses after 14 to 149 days, 64% for 2 doses after at the very least 150 days (however the 95% confidence interval ranged beneath 0), 86% for 3 doses after 7 to 119 days, and −53% for 3 doses given at the very least 120 days earlier than. Estimated VE in opposition to ED/UC visits was 3%, 42%, 79%, and -124%, respectively.
The authors famous that COVID-19 throughout being pregnant is linked to an elevated danger of hospitalization, intensive care unit (ICU) admission, preterm beginning, and stillbirth. But, regardless of present steering from the CDC and the American School of Obstetricians and Gynecologists, COVID-19 vaccine uptake stays low amongst pregnant ladies.
The researchers stated that the outcomes “recommend that mRNA vaccine administration throughout being pregnant doesn’t alter vaccine efficiency regardless of immune variations between pregnant and nonpregnant folks.”
Sep 26 JAMA Netw Open study