CSF biomarkers help AD prognosis in practically 90% of medical instances

August 03, 2022

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Agüero P, et al. CSF Alzheimer’s biomarkers in medical follow. Introduced at: Alzheimer’s Affiliation Worldwide Convention; July 31-Aug. 4; San Diego.

Disclosures: Aguero experiences no related monetary disclosures.

SAN DIEGO — Cerebrospinal fluid biomarkers supported the medical prognosis of Alzheimer’s illness in a small cohort of sufferers, per a poster presentation on the Alzheimer’s Affiliation Worldwide Convention.

“We analyzed the usage of biomarkers in our medical setting … [to check] the accuracy by which these biomarkers function a diagnostic instrument within the medical setting of a traditional affected person with suspected Alzheimer’s illness,” Pablo Agüero, MD, of Jiménez Díaz Basis College Hospital in Madrid, stated.

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Agüero and colleagues analyzed 141 consecutive CSF samples of sufferers with suspected cognitive decline who had been referred to the hospital’s reminiscence clinic and utilized the Lumipulse G600II chemiluminescent immunoassay (Fujirebio) to find out the ratio of beta-amyloid 42, the 42/40 ratio, complete Tau and phospho-Tau.

Researchers divided medical diagnoses into AD, degenerative non-AD and non-degenerative, given medical standards at sufferers’ earlier visits. They then separated the teams primarily based on biomarkers: detrimental for AD (A–T–N– and A–T–N+), constructive for AD (A+T+N+ and A+T+N–), instances with amyloidosis A+ however T– (A+T–N+; A+T–N–) and instances with out amyloidosis A– however T+ (A–T+N+).

In keeping with outcomes, 50% of sufferers confirmed a constructive AD consequence, which coincided with medical amnestic AD phenotype or different associated phenotypes, whereas 37% had a detrimental AD consequence that correlated to both non-AD neurodegenerative or non-degenerative diagnoses.

Nevertheless, researchers discovered 13% of instances had inconsistencies inside biomarkers, notably with A– (n = 7) and A+ (n = 11) outcomes. With respect to medical diagnoses, all sufferers with A–T+N+ and eight of 11 sufferers with A+ biomarkers had been thought of AD phenotypes. In two instances of the previous, AD diagnoses had been later confirmed by way of constructive PET-amyloid research and full constructive CSF biomarkers.

“These biomarkers are a very helpful diagnostic instrument,” Agüero stated. “Generally, nearly 90%, they offer a really clear reply if the affected person has [or doesn’t have] Alzheimer’s illness resulting from cognitive decline. And in these instances, by which the outcomes should not clear, they are typically Alzheimer’s illness.”


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