August 12, 2022
2 min learn
Disclosures: De Souza studies no related monetary disclosures. Please see the examine for all different authors’ related monetary disclosures.
In postmenopausal ladies, consuming prunes day-after-day prevented lack of hip bone mineral density and guarded towards hip fractures, in line with a randomized managed trial printed in The American Journal of Scientific Diet.
“Our information helps using prunes to guard the hip from bone loss post-menopause,” Mary Jane De Souza, PhD, FACSM, distinguished professor of kinesiology and physiology and director of the Girls’s Well being and Train Laboratory at Pennsylvania State College, stated in a press launch. “Certainly, these information could also be particularly priceless for postmenopausal ladies who can’t take pharmacological remedy to fight bone loss and want an alternate technique.”
De Souza and colleagues randomly assigned 235 ladies (common age, 62.1 ± 5 years; 97% white) to eat 50 g of prunes every day for 1 12 months (n = 79), 100 g of prunes every day for 1 12 months (n = 78) or to a management group (n = 78). Controls have been prescribed calcium and vitamin D3 as wanted to satisfy the beneficial every day allowance.
The researchers assessed the consequences of dietary intervention on bone mineral density (BMD) and bone biomarkers each 6 months.
Though 90.2% and 87.1% of girls consuming 50 g and 100 g of prunes, respectively, have been compliant with the intervention, the dropout fee was considerably increased amongst these assigned to eat 100 g of prunes (41%) in contrast with the charges within the 50 g group (15%) and the management group (10%).
Modifications in BMD, fracture threat
Mary Jane De Souza
Complete hip BMD measurements revealed that ladies who ate 50 g of prunes — or six prunes — day-after-day preserved BMD on the 6- and 12-month assessments. Additionally they had a considerably smaller lower in BMD between baseline and 12 months in contrast with the management group (–0.27% ± 0.2% vs. –1.1% ± 0.2%; P = .011).
The group consuming 100 g of prunes — or 12 prunes — every day didn’t expertise the identical hip BMD profit because the 50 g group when put next with the management group. These ladies did, nonetheless, have a decrease threat for main osteoporotic fracture in contrast with the management group (P = .03).
Pooled prune analyses
In pooled analyses, the management group misplaced considerably extra complete hip BMD in contrast with the prune group (1.1% ± 0.2% vs. 0.25% ± 0.2%; P = .007). The management group had a higher threat for hip fracture at 6 months and a higher threat for main osteoporotic fracture at 6 and 12 months in contrast with baseline (all, P < .05). Then again, members within the prune group maintained their threat for hip fracture and main osteoporotic fracture via 12 months.
Pooled analyses of bone biomarkers and hormones revealed that each the management group and the prune group skilled will increase in insulin-like progress factor-1 and 25-hydroxyvitamin D.
Regardless of the findings that every day prune consumption could also be a non-pharmacological choice for preserving BMD, De Souza and colleagues suggested that “the magnitude of the impact of prune remedy on bone density will not be corresponding to osteoporosis treatment.”