Endocannabinoid deficiency might play a task in migraine

June 21, 2022

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Largent-Milnes T. How does the endocannabinoid system have an effect on headache and issues? Introduced at: American Headache Society annual scientific assembly; June 9-12, 2022; Denver.

Disclosures: Largent-Milnes reviews no related monetary disclosures.

DENVER — There could also be a hyperlink between migraine and scientific endocannabinoid deficiency, a speaker mentioned on the American Headache Society’s annual scientific assembly.

“That has actually come from this concept that when you measure endocannabinoid lipid ranges, from platelets or [cerebrospinal fluid] from migraine sufferers or those that have medicine overuse, they really have considerably decrease ranges of circulating endocannabinoid lipids,” Tally Largent-Milnes, PhD, assistant professor of pharmacology on the College of Arizona, mentioned.

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Largent-Milnes famous that when evaluating endocannabinoid ranges in cerebrospinal fluid and platelets, there have been no 2-arachidonoylglycerol (2-AG) endocannabinoid lipids.

“That is very odd, as a result of 2-AG is definitely the extra dominant endocannabinoid lipid, and it is expressed and made at 200-fold extra concentrated ranges than anandamide itself,” she mentioned.

Largent-Milnes and colleagues utilized preclinical fashions to know the hyperlink between migraine and endocannabinoid deficiency. They used medicine overuse fashions and measured periorbital withdrawal thresholds and endocannabinoid lipids.

In line with Largent-Milnes, 2-AG have been nonetheless low, whereas anandamide was elevated, which suggests a “distinctive sample” for the endocannabinoid system.

“I’ve proven you that endocannabinoids do play a task in headache, each headache pathogenesis and upkeep, and that they could be focused on the enzyme degree for treating various kinds of headache pains,” she mentioned.


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