Monumental rise in Acinetobacter bloodstream an infection circumstances in preliminary two years of COVID-19

In a current research revealed in Eurosurveillance, researchers investigated Acinetobacter species bloodstream an infection (BSI) case counts from a subset of laboratory knowledge constantly reported through the preliminary two years of extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections from 2020 to 2021.

Study: Increasing number of cases and outbreaks caused by Candida auris in the EU/EEA, 2020 to 2021. Image Credit: Kateryna Kon/Shutterstock
Examine: Increasing number of cases and outbreaks caused by Candida auris in the EU/EEA, 2020 to 2021. Picture Credit score: Kateryna Kon/Shutterstock

Research have reported poor outcomes of Acinetobacter BSIs, significantly amongst ICU (intensive care unit)-admitted people. The bacterial organism has intrinsic resistance to a number of antimicrobial brokers, and moreover, acquired resisting skills might additional complicate therapy regimens amongst susceptible people.

Not too long ago revealed EARS-Web (European antimicrobial resistance surveillance community) knowledge confirmed a major rise in Acinetobacter BSIs amongst EU/ EUA (European Union/European financial space) nations between 2017 and 2021. A significant fraction of the rise was discovered to happen within the 2020 to 2021 interval, the preliminary years of the SARS-CoV-2 pandemic.

Concerning the research

Within the current research, researchers evaluated the rise in Acinetobacter BSIs through the preliminary two years of coronavirus illness 2019 (COVID-19) between 2020 and 2021.

The information analyzed within the current research originated from qualitative common AST (antimicrobial susceptibility testing) studies of blood samples obtained by regionally primarily based laboratories within the national-level networks of EU/EEA nations. The laboratory testing outcomes documented yearly by national-level facilities to ECDC (European centre for illness prevention and management), following the EARS-Web documentation protocols, have been analyzed. Solely the preliminary isolate of each particular person per 12 months per bacterium was included within the Ears-Web knowledge.

All European Union nations, Norway and Iceland have submitted data to the EARS-Web system annually between 2017 and 2021; nevertheless, for the current evaluation, the dataset was restricted to Acinetobacter BSIs knowledge from laboratories (255 out of 826 medical laboratories) that documented outcomes of carbapenem (meropenem and/or imipenem) susceptibility testing for Acinetobacter species annually between 2017 and 2021.

Information have been restricted to scale back bias from annual variations in hospital affiliations, quantity, and reporting kind of laboratories since all nations couldn’t distinguish between medical laboratories with no documented circumstances and laboratories with no such circumstances.

Information from the UK (United Kingdom) was not included for the reason that nation had withdrawn from the EU in 2020. Moreover, knowledge from France was not included since only some medical laboratories have been identifiable constantly after the reorganization of national-level surveillance in 2020. The chances of Acinetobacter resistance diverse significantly between the EU/EEA nations. Subsequently, the nations have been grouped primarily based on common percentages of their nationwide yearly carbapenem resistance reported through the 2018 to 2019 interval. Poisson regression modeling was used to evaluate the variations in BSI counts and carbapenem resistance percentages between 2020 to 2021 and 2018 to 2019.


Group 1 nations (n=13) had lower than 10% resistance to carbapenem and included the Netherlands, Belgium, Austria, Estonia, Denmark, Germany, Iceland, Finland, Luxembourg, Eire, Norway, Sweden, and Malta. Group 2 nations (n=3) had resistance to carbapenem between 10% and 50% and included Slovenia, Czechia, and Portugal. Group 3 nations (n=12) had equal to or better than 50% resistance to carbapenem and included Croatia, Bulgaria, Greece, Cyprus, Italy, Hungary, Lithuania, Latvia, Romania, Poland, Spain, and Slovakia.

Additional, the models have been grouped primarily based on the ward varieties as ‘ICU’ (together with pediatric and grownup ICU models), ‘not ICU’ (together with ward varieties apart from ICUs), and ‘unknown’ (knowledge on the kind of ward was unavailable). In whole, Acinetobacter species BSIs documented between 2020 and 2021 rose by 57% in comparison with the interval between 2018 and 2019. The rise was largely on account of BSIs by Acinetobacter species proof against carbapenem, with case counts rising by 114% and the share of resistance to carbapenem rising from 48% between 2018 and 2019 to 66% between 2020 and 2021.

The rise in BSIs brought on by Acinetobacter species proof against carbapenem was noticed to be better in ICU-admitted people (144%) than non-ICU-admitted people (41%). The slight enhance in BSIs brought on by Acinetobacter species inclined to carbapenem BSIs throughout 2020 and 2021 compared to the interval between 2018 and 2019 didn’t present statistical significance.

The rise (116%, n=5,472)) in Acinetobacter species BSI circumstances between 2020 and 2021 was most outstanding amongst Group 3 nations, in comparison with 2,529 circumstances documented within the 2018 to 2019 interval. Amongst Group 2 nations, an analogous enhance (109%) was noticed. Nonetheless, with lesser reported circumstances per nation, Group 1 nations documented solely 52 circumstances between 2020 and 2021, with no vital distinction in case counts documented between 2018 and 2019 (n=54).


General, the research findings confirmed an infinite enhance in BSIs brought on by Acinetobacter species proof against carbapenem amongst EU/EEA nations through the preliminary two years of the COVID-19 pandemic, a difficult interval for well being authorities throughout the globe. The findings confirmed that controlling the additional unfold of Acinetobacter was most difficult for Group 3 nations the place carbapenem-resistant Acinetobacter species have been prevalent within the pre-pandemic interval.

The patterns of Acinetobacter species BSI noticed amongst EU/EEA nations have raised world considerations since carbapenem resistance has brought on a substantial illness burden amongst susceptible and hospitalized people. Subsequently, continued surveillance efforts are required to watch alterations in carbapenem resistance and Acinetobacter BSI growth.

Journal reference:



Leave a Reply