LMU scientists reveal that interactions between RNA-binding proteins have an effect on translation and consequently the complexity of neurons.
Neurons continuously adapt to new necessities. This plasticity is the molecular basis of studying and remembering. On the mobile degree, there’s a wide range of mechanisms for regulating basic gene expression. One of many main gamers is RNA-binding proteins, which acknowledge messenger molecules (mRNA). On this manner, they regulate the place and when proteins could be produced contained in the neuron. Collectively with different elements, the Staufen2 and Argonaute RNA-binding proteins type RNA granules within the cytoplasm.
A group led by LMU cell biologist Prof. Michael Kiebler has now proven for the primary time how Staufen and Argonaute proteins work together with one another. The authors of the examine revealed in Nucleic Acid Analysis had been in a position to reveal that the 2 RNA-binding proteins compete with one another in fulfilling their operate. Their outcomes counsel that on this manner the 2 RNA-binding proteins regulate the interpretation of particular proteins within the dendrite and on the synapse. The scientists hypothesize that these meeting dynamics of RNA granules make an essential practical contribution to synaptic plasticity, significantly in neurons.
Ehses, J., et al. (2022) The dsRBP Staufen2 governs RNP meeting of neuronal Argonaute proteins. Nucleic Acids Analysis. doi.org/10.1093/nar/gkac487.