Information Scan for Jun 21, 2022

UK expands monkeypox vaccination to extra danger teams

The UK right this moment expanded monkeypox vaccination to incorporate males who’ve intercourse with males who’re in high-risk teams, as a substitute of simply those that are recognized contacts and people at occupational danger.

In an replace, the UK’s Well being Safety Company (HSA) mentioned the chance standards now consists of individuals who have not too long ago had a number of intercourse companions, take part in group intercourse, attend sex-on-premises venues, and have a proxy marker equivalent to a latest bacterial sexually transmitted an infection previously yr.

In different developments, the UK reported 219 extra instances over a 4-day interval, in accordance with the HSA’s newest replace. The brand new instances raise its whole to 793 as of Jun 20. The best proportion, 80%, contain London residents.

In america, New Jersey yesterday introduced its first possible case, a affected person who examined optimistic for orthopox on Jun 18 whose samples will endure confirmatory monkeypox testing on the Facilities for Illness Management and Prevention (CDC). The affected person is isolating at house, and the New Jersey Division of Well being (NJDOH) had no different particulars in regards to the affected person or publicity.
Jun 21 UK HSA vaccination update
Jun 21 UK HSA
Jun 20 NJDOH


Research: Hospitalized Omicron sufferers benefited from fourth vaccine dose

When the Omicron variant surge hit on the finish of 2021, which got here with breakthrough COVID-19 infections in vaccinated individuals, Israel was one of many first international locations to supply fourth vaccine doses for these age 60 and older. Yesterday, Israeli researchers reported {that a} fourth dose was linked to important safety in opposition to extreme outcomes in hospitalized sufferers.

In a multicenter retrospective cohort research, they examined outcomes in individuals who have been hospitalized within the final half of January, on the lookout for any variations in outcomes between those that obtained three and those that obtained 4 doses. Most individuals in Israel obtained the Pfizer-BioNTech vaccine. The workforce revealed its findings in Medical Infectious Illnesses.

They analyzed outcomes of 1,049 sufferers, defining poor outcomes as mechanical air flow or dying. Of the group, 394 have been unvaccinated, 386 had obtained three doses, and 88 had gotten a fourth dose. The three-dose group, which had extra males and immunocompromised individuals, had related extreme outcomes to the unvaccinated group, which have been 49% and 51%, respectively.

Although individuals who obtained their fourth doses had related age and immune compromise profiles, they’d higher outcomes than unvaccinated individuals (34% vs 51%).

“These findings recommend that administration of a recent booster dose needs to be thought of for at-risk people upon an impending new COVID-19 wave,” the group wrote.
Jun 20 Clin Infect Dis abstract

US COVID markers present declines, however BA.4 and BA.5 ranges rising

US COVID-19 exercise seems to be lowering or stabilizing, with the 7-day common for brand spanking new instances now under 100,000. In accordance with a Washington Put up evaluation, the 7-day common is at 94,437, down 11.9% from per week in the past. Nonetheless, it is tough to get a extra exact evaluation, given lowered testing and the broader use of at-home exams.

In the meantime, the proportions of BA.4 and BA.5 Omicron subvariants, that are extra transmissible and have mutations linked to immune escape, are steadily rising. In its newest estimates, the CDC mentioned right this moment that BA.4 and BA.5 make up about 35% of sequenced SARS-CoV-2 samples, up from about 23% the week earlier than. The south-central area has the best proportion of two subvariants. That area consists of Arkansas, Louisiana, New Mexico, Oklahoma, and Texas.

Hospitalizations seem steady, as are deaths, which common about 300 per day.

Late final week, the CDC mentioned practically 61% of the US inhabitants lives in areas with medium or excessive COVID-19 neighborhood ranges, down from 67% the earlier week.
Washington Put up COVID-19 tracker
variant estimates
community transmission estimates



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