Older adults with hypothyroidism at elevated danger for dementia

July 06, 2022

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People aged 65 years and older with a historical past of hypothyroidism have been related to an 81% elevated danger for dementia, researchers reported in Neurology.

“In some circumstances, thyroid issues have been related to dementia signs that may be reversible with remedy,” Chien-Hsiang Weng, MD, MPH, scientific assistant professor at Brown College Warren Alpert Medical College and doctor at Coastal Medical Hillside Household Drugs, mentioned in a associated press launch.

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Weng and colleagues performed a nationwide population-based, case-control examine and utilized the Taiwanese Nationwide Well being Insurance coverage Analysis Database to determine 7,843 adults with newly recognized dementia (imply age, 74.9 years), who have been matched with the identical variety of adults with out dementia (imply age, 74.5 years). Of 15,686 whole members, 102 had hypothyroidism, and 133 had hyperthyroidism.

Researchers reported an elevated danger for being recognized with dementia in sufferers aged 65 years and older with a historical past of hypothyroidism (adjusted OR = 1.81; 95% CI, 1.14-2.87). This affiliation was not noticed in sufferers older than 50 years however youthful than 65 years.

As well as, researchers famous there was a threefold improve in dementia danger amongst sufferers aged 65 years and older who acquired hypothyroidism medicine (aOR = 3.17; 95% CI, 1.04-9.69).

Weng and colleagues discovered no affiliation between hyperthyroidism and dementia.

“Whereas extra research are wanted to substantiate these findings, individuals ought to concentrate on thyroid issues as a doable danger issue for dementia and therapies that would stop or gradual irreversible cognitive decline,” Weng mentioned.


American Academy of Neurology. Thyroid problems linked to increased risk of dementia. Printed July 6, 2022. Accessed July 6, 2022.


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