Constructive airway stress could gradual cognitive decline in adults with obstructive sleep apnea

Might 12, 2022

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Disclosures: Moon reviews assist by a T32 grant from Nationwide Coronary heart, Lung and Blood Institute. Please see the research for all different authors’ related monetary disclosures.

Constructive airway stress remedy could delay cognitive decline in adults with obstructive sleep apnea, however extra analysis is required, based on a scientific evaluation revealed in Neurology.

“Though latest work has recognized [obstructive sleep apnea] as a doubtlessly modifiable threat issue for cognitive decline and dementia, relationships between constructive airway stress remedy — the gold customary [obstructive sleep apnea] remedy — and neurocognitive problems are poorly understood,” Monica Moon Shieu, PhD, MS, of the division of neurology’s division of sleep drugs on the College of Michigan, and colleagues wrote.

Older adult looking confused
Supply: Adobe Inventory.

To higher perceive the impression of positive airway pressure (PAP) therapy on incidence of cognitive problems and decline in middle-aged and older adults with obstructive sleep apnea (OSA), Shieu and colleagues searched MEDLINE, EMBASE, CINAHL and Scopus databases to establish 11 research that highlighted associations between PAP remedy and subsequent cognitive problems.

Outcomes confirmed that inside the 11 research, 96% of members (n = 60,840) had OSA whereas 5,826 had both gentle cognitive impairment or Alzheimer’s illness. Amongst all members, 43,973 obtained PAP remedy and 16,397 went untreated or had been positioned in a placebo group.

Researchers additionally discovered that almost all of research revealed a slower price of cognitive decline in those that utilized PAP remedy, with solely two research reporting no protecting results of PAP in delaying cognitive decline. Nevertheless, information on the speed of decline in relation to PAP remedy stays blended.

“Findings relating to the impression of PAP remedy on cognitive decline had been promising, though bigger research with longer follow-up are warranted,” Shieu and colleagues wrote.


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