Probiotic complement improves bothersome vaginal odor, signs at ‘warp velocity’

October 14, 2022

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Kellogg Spadt S, et al. Summary P-35. Offered at: North American Menopause Society Annual Assembly; Oct. 12-15, 2022; Atlanta.

Disclosures: Kellogg Spadt reviews serving as a researcher and guide for Bonafide Well being.

Girls who took a probiotic complement for bothersome vaginal odor and signs equivalent to irritation and painful urination reported substantial enhancements inside 2 weeks, based on research findings introduced on the NAMS Annual Assembly.

The probiotic, Clairvee (Bonafide Well being), is meant for ladies who report a vaginal odor “totally different than that which they assume is regular for them” and different bothersome signs however who wouldn’t have an an infection, based on Susan Kellogg Spadt, PhD, CRNP, director of feminine sexual drugs on the Middle for Pelvic Medication, Tutorial Urology of PA in Bryn Mawr, Pennsylvania.

Data derived from Kellogg Spadt S, et al. Abstract P-35. Presented at: North American Menopause Society Annual Meeting; Oct. 12-15, 2022; Atlanta.
Knowledge derived from Kellogg Spadt S, et al. Summary P-35. Offered at: North American Menopause Society Annual Assembly; Oct. 12-15, 2022; Atlanta.

“[These women] are usually not contaminated, however they’re not feeling like that is regular for them, and perhaps they don’t significantly look after the brand new scents, or they only assume it’s totally different,” Kellogg Spadt advised Healio. “[This probiotic] was being developed predominantly for ladies who complained of power yeast or bacterial vaginosis, each of that are authentic vaginal infections. However what about that cadre of girls who doesn’t have an an infection, however who may benefit from this intervention?”

Kellogg Spadt and colleagues enrolled ladies from three medical facilities throughout the US in two open-label trials of Clairvee lasting 4 weeks. Girls took one capsule each day for 15 consecutive days every month. Capsules contained 400 µg of dietary folate equal; 5 billion colony-forming items of a vaginal mix of Lactobacillus acidophilus and L. rhamnosus; and 50 mg of lactoferrin.

Individuals accomplished the Vulvovaginal Signs Questionnaire (VSQ) each 2 weeks beginning at baseline to price severity of vaginal signs, satisfaction with the probiotic, and affect of the probiotic on life typically and on sexual exercise, if the participant was sexually lively.

Clairvee for bothersome odor

The primary research included 33 ladies aged 24 to 70 years who had no vaginal an infection however reported bothersome vaginal odor, all of whom reported enchancment for a minimum of one vaginal symptom — equivalent to itching, discharge, burning, dryness, odor, irritation or painful urination — inside 4 weeks.

At 2 weeks, 63% of girls reported improved vaginal odor. At 4 weeks, 75% reported enhancements in odor. Enhancements had been important at each timepoints (P < .01), based on the researchers. Of word, 30% of girls reported an absence of odor at 2 and 4 weeks.

In accordance with Kellogg Spadt, these enhancements occurred at “warp velocity.”

Susan Kellogg Spadt, PhD, CRNP

Susan Kellogg Spadt

“At 2 weeks and 4 weeks, ladies had been already saying issues had been altering fairly dramatically,” Kellogg Spadt mentioned. “That’s the factor that was most stunning to me, as I assumed that we’d see a sign at 4 weeks, or perhaps we should always have prolonged the research and made it longer, however instantly, folks had been saying one thing’s altering.”

Amongst sexually lively ladies, mixed VSQ scores improved from baseline by way of week 2 and thru week 4 (each P < .01).

Moreover, 84% of girls mentioned the dosing routine was “handy,” and greater than half had been glad with therapy after 2 weeks.

Clairvee for vaginal signs

For the second research, Kellogg and colleagues included ladies aged 24 to 82 years who had no vaginal infection however reported vaginal signs. At 2 and 4 weeks, enhancements in vaginal signs had been reported (each P < .05).

Amongst sexually lively ladies, 40% reported extra sexual want, 41% reported improved sexual relationships, 41% reported much less ache throughout sexual exercise, 48% reported much less dryness with sexual exercise, 24% reported much less bleeding throughout sexual exercise and 39% reported fewer vaginal signs regarding sexual exercise.

A 6-month extension trial of Clairvee is ongoing to guage whether or not the enhancements noticed in these research are sustainable, Kellogg Spadt mentioned.


  • Kellogg Spadt S, et al. Summary P-35. Offered at: North American Menopause Society Annual Assembly; Oct. 12-15, 2022; Atlanta.
  • Kellogg Spadt S, et al. Summary P-36. Offered at: North American Menopause Society Annual Assembly; Oct. 12-15, 2022; Atlanta.

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