Tezepelumab reduces mucus plugging in sufferers with average to extreme uncontrolled bronchial asthma

September 16, 2022

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Supply:

Brightling CE, et al. ALERT 4: Bronchial asthma and Interventional Pulmonology. Introduced at: European Respiratory Society Worldwide Congress; Sept. 4-6, 2022 (hybrid assembly).

Disclosures:
Brightling studies receiving grants, analysis assist, honoraria or marketing consultant charges from 4D Pharma, AstraZeneca, Chiesi, Genentech, GlaxoSmithKline, Mologic, Novartis, Regeneron, Roche and Sanofi.


Tezepelumab therapy lowered mucus scores, which correlated with lung operate enchancment, amongst sufferers with average to extreme uncontrolled bronchial asthma, researchers reported on the European Respiratory Society Worldwide Congress.

“It’s the primary time we’ve been in a position to display in a randomized managed trial discount of mucus plugging in response to a biologic remedy focused extraordinarily nicely vs. placebo,” Christopher E. Brightling, MD, PhD, Nationwide Institute for Well being and Care Analysis (NIHR) senior investigator and scientific professor in respiratory drugs on the College of Leicester, U.Okay., stated throughout a presentation.

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Brightling offered outcomes of an exploratory publish hoc analysis of the phase 2, double-blind, placebo-controlled CASCADE study. Researchers randomly assigned 116 sufferers aged 18 to 75 years with average to extreme uncontrolled bronchial asthma to therapy with subcutaneous tezepelumab-ekko 210 mg (Tezspire, Amgen/AstraZeneca) or placebo each 4 weeks for 28 weeks. A radiologist scored mucus plugging at baseline and on the finish of the therapy interval in 18 lung segments utilizing CT imaging. Mucus plugs have been outlined as capacities that utterly occluded the lumen of the segmental or subsegmental airway, Brightling stated.

Baseline distribution of mucus scores was much like that beforehand described in sufferers with extreme bronchial asthma, Brightling stated in the course of the presentation.

At baseline, there was a optimistic correlation between affected person mucus rating and blood eosinophils, eosinophil-derived neurotoxin, fractional exhaled nitric oxide, interleukin (IL)-5 and IL-13. The researchers reported a damaging correlation between affected person mucus rating and pre-bronchodilator FEV1 and compelled expiratory circulation of 25% to 75%.

In contrast with placebo, therapy with tezepelumab lowered mucus plugging scores; the imply change was –1.7 amongst 37 sufferers within the tezepelumab group and 0 amongst 45 sufferers within the placebo group (P = .0007).

The discount in mucus plugging rating correlated with enhancements in lung operate measured by pre-bronchodilator FEV1 (P = .00014) and compelled expiratory circulation of 25% to 75% (P = .0006), Brightling stated.

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