Distinctive 3D printed system for wide-scale manufacturing of stem cells

Researchers have developed a novel 3D printed system for harvesting stem cells from bioreactors, providing the potential for top of the range, wide-scale manufacturing of stem cells in Australia at a decrease price.

Stem cells supply nice promise within the therapy of many illnesses and accidents, from arthritis and diabetes to most cancers, resulting from their potential to switch broken cells. Nevertheless, present know-how used to reap stem cells is labor intensive, time consuming and costly.

Biomedical engineer Professor Majid Warkiani from the College of Know-how Sydney led the translational analysis, in collaboration with trade companion Regeneus – an Australian biotechnology firm growing stem cell therapies to deal with inflammatory circumstances and ache.

Our cutting-edge know-how, which makes use of 3D printing and microfluidics to combine quite a few manufacturing steps into one machine can assist make stem cell therapies extra extensively out there to sufferers at a decrease price.”

Professor Majid Warkiani, College of Know-how Sydney

“Whereas this world-first system is at the moment on the prototype stage, we’re working carefully with biotechnology corporations to commercialize the know-how. Importantly, it’s a closed system with no human intervention, which is important for present good manufacturing practices,” he stated.

Microfluidics is the exact management of fluid at microscopic ranges, which can be utilized to govern cells and particles. Advances in 3D printing have allowed for the direct building of microfluidic tools, and thus fast prototyping and constructing of built-in programs.

The brand new system was developed to course of mesenchymal stem cells, a sort of grownup stem cell that may divide and differentiate into a number of tissue cells together with bone, cartilage, muscle, fats, and connective tissue.

Mesenchymal stem cells are initially extracted from human bone marrow, fats tissue or blood. They’re then transferred to a bioreactor within the lab and mixed with microcarriers to permit the cells to proliferate.

The brand new system combines 4 micromixers, one spiral microfluidic separator and one microfluidic concentrator to detach and separate the mesenchymal stem cells from microcarriers and focus them for downstream processing.

The research ‘A modular 3D printed microfluidic system: a possible answer for steady cell harvesting in massive‑scale bioprocessing’ was just lately revealed within the journal Bioresources and Bioprocessing.

Professor Warkiani stated different bioprocessing industrial challenges will also be addressed utilizing the identical know-how and workflow, serving to to scale back prices and enhance the standard of a variety of life-saving merchandise together with stem cells and CAR-T cells.

Journal reference:

Ding, L., et al. (2022) A modular 3D printed microfluidic system: a possible answer for steady cell harvesting in large-scale bioprocessing. Bioresources and Bioprocessing. doi.org/10.1186/s40643-022-00550-2.



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